What is in this article?:
- A better mouse, not a better mousetrap
- More perfect mouse
- Mouse science may benefit human and animal health.
- Genetically defined mouse models would offer a tractable experimental system for mapping the genes underlying disease and for examining their function in the context of a complex human body.
- Geneticists can begin to look deeper into conditions like diabetes and heart disease.
More perfect mouse
The solution in this case seemed to be a better mouse instead of a better mouse trap, and before long Churchill went to work on the idea in his lab and eventually developed a more perfect mouse. Through a comprehensive breeding program and using only limited funding sources, he created a super mouse, but breeding the mice in sufficient quantity to have a major impact on genetic research promised to be a monumental and costly task.
It was time for more innovative thinking, and before long Churchill had secured the support of a number of independent laboratories in Tennessee, Kenya and Australia, and collectively developed a mice population bred from eight founding mouse strains to encompass 90-percent of the diversity of the whole mouse genome, a number more in line with the amount of variation in the human genome.
Ten years later the project has finally found a home at the University of North Carolina at Chapel Hill where over 400 “CC” mouse strains are under development, and Churchill says already the rodent medical soldiers are being shipped to labs around the world with designs of tackling such diverse human genetics as those involved in cancer, aging, fertility and more.
Because of the new CC strain, geneticists can begin to look deeper into conditions like diabetes and heart disease, giving rise to hope that science may soon be able to provide treatments and medications that could help with age-old health problems for the human race.
Already scientist have began using the new mouse population for studying human host response to the flu, realizing that modern vaccines are limited because they were designed to treat all recipients the same regardless of individual health conditions. For instance, a perfectly health young adult receives the same vaccine as a senior over 65 years with underlying health conditions. New vaccines may be developed that could take these human conditions into consideration, developing vaccines to better fit people based upon their health conditions.
The new mouse population may also offer future benefits to agriculture. With the antibiotics in animal feed controversy resurfacing in federal court, geneticists say medical research related to farm animals using the new mouse strain could offer advanced treatments and medicines for veterinarian application that could help make food safer for consumption and animals healthier on the farm.
The next step is for scientists to develop better methods of storing phenotypic data about the mice and exploring other ways they can be used to address a wide range of health issues including both animal and human conditions.