What is in this article?:
- Nuclear Magnetic Resonance technique, commonly called NMR, is the forerunner of the more widely known MRI.
- New NMR to be fully operational by the first of September.
- The equipment will benefit researchers from across Texas A&M.
“The business component of an NMR spectrometer is a very large, super-conducting magnet the strength of which is measured by the frequency of protons that resonate in it,” said Dr. Tatyana Igumenova, a biochemist and director of the Biomolecular NMR facility. “By today’s standards this is considered to be a very high-field instrument.”
One common application of the high-field NMR, she said, is in drug design.
“NMR offers a very quick and easy way to test if a drug candidate binds to a particular protein or enzyme, for example,” she said. “If you can map the binding site and understand what a particular drug candidate is doing to the protein structure and dynamics, this in turn would enable you to design even better therapeutic agents.”
Because the new equipment also has a CryoProbe, or cold probe that keeps the electronics responsible for signal detection at the temperature of helium gas, less noise is generated and that leads to improved signals, Igumenova said. In essence, what would have been a two-day experiment on the existing equipment could now be done in half a day.
Reinhart said Texas A&M researchers will now have better access to three complementary methods in structural biology research: x-ray crystallography, electron microscopy, and NMR spectroscopy.
“These methods serve different purposes,” he said. “With x-ray crystallography, the sample is immobile because it has been crystallized so that limits what can be studied about function but the structural information is very precise. Electron microscopy doesn’t afford the atomic resolution but it images anything so one doesn’t have to have pure samples.
“The NMR does not quite have the precision of X-ray but it comes close, and one can observe the molecule in solution, which is more like its native environment and with motion, which is important to understanding function.”
Igumenova said graduate and undergraduate students will be trained to use the equipment as well as to process and interpret the data. She also plans to use a portion of her National Science Foundation Faculty Early Career Development Grant to provide opportunities for underrepresented students to use the equipment in studies.
“It’s a stepping stone into even greater research opportunities in the future,” Reinhart said.